PREDICTOR FACTORS for MULTIDRUG-RESISTANT TUBERCULOSIS among PATIENTS with PULMONARY TUBERCULOSIS in HUÁNUCO, Peru. 2010-2015

Introduction: In the city of Huánuco and around the world, there is a progressive increase in cases of tuberculosis and multidrug-resistant tuberculosis, for this reason it was necessary to identify predictors to develop multidrug-resistant tuberculosis. Objective: To determine if persistent fever, cavitary radiographic pattern and positive smear microscopy at the first month of treatment, are predictors of multidrug-resistant tuberculosis in patients with pulmonary tuberculosis, in four health facilities in the city of Huánuco, between January 2010 and December 2015. Methods: Case and control study. We considered 37 cases and 111 controls. Data were collected from medical records. Results: The predictive factors found in the bivariate analysis were persistence of fever at 2 weeks (p = 0.001, OR 0.05, CI 0.01-0.5), cavitary radiographic pattern (p = 0.000, OR 11.6, 95%IC 4.6-26.5), and smear microscopy positivity at the first month of treatment (p = 0.00, OR 13.5, 95%CI 4.1-44.6). These were confirmed by multivariate analysis (p = 0.012, p = 0.00, p = 0.00 respectively). Conclusion: The persistence of fever at two weeks, cavitary radiographic pattern and positive smear microscopy at the first month of treatment were predictive factors associated independently for the diagnosis of multidrug-resistant Tuberculosis.